New paper on bipolar cell survival in the developing mouse cortex

Continuing our understanding on the role of programmed cell death in shaping the interneuron population in the developing mouse cortex, Fong has recently published a paper on Cell Reports. In this paper, she has shown that interneuron survival is regulated in an input-specific manner during the period of programmed cell death. More specifically, the neurogliaform and the caudal-ganglionic eminence derived basket cells rely on glutamatergic neurotransmissions. Bipolar cells survival however, do not depend on glutamate but instead depends on the long-range serotonergic inputs.


To find out more, you can read the full paper at https://www.cell.com/action/showPdf?pii=S2211-1247%2822%2900831-2.


We have also summarised the main message of the paper in the following comic



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